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| Caption | Histological and echocardiographic analysis of hearts from adult Hbegftm2Mek/Hbegftm2Mek (uc/uc) mice. A and B: Hematoxylin and eosin staining of transverse sections through hearts of 12 week old mice at the papillary muscle level. Bar, 3 mm. C and D: High magnification pictures. Sections were stained with Azan-Mallory. Massive fibrosis (blue stain) is present in 12 week old Hbegftm2Mek/Hbegftm2Mek heart throughout the vessel wall. Bar, 250 um. E and F: Echocardiographic analyses of hearts from wild-type (+/+) and mutant mice. E: Representative images of M-mode analyses are shown. Arrows indicate end-diastolic (d) and end-systolic (s) dimensions, respectively. F: Physiological parameters of wild-type versus mutant hearts in 12 week old mice. HR, heart rate, sBP and dBP, systolic and diastolic blood pressure; LVDd and LVDs, left ventricular end diastolic and end systolic internal dimensions; FS, percent fractional shortening calculated as [(LVDd-LVDs)/LVDd] x 100. All values +/- SEM. | ||||
| Copyright | This image is from Yamazaki S, J Cell Biol 2003 Nov 10;163(3):469-75, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:86547 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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