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Phenotype Image Detail
Image
Caption Ultrastructure of central nervous system (CNS) and peripheral nervous system (PNS) nodes of Ranvier (NR) in wild-type (+/+) and Sptbn4tm1Msol/Sptbn4tm1Msol (-/-) mice. EM of the optic (A-D) and sciatic (E-K) nerves from adult wild-type (A,B,E and F) and mutant (C,D and G-K). Arrows and insets show the coat beneath the NR membrane. Arrowheads show the protrusions in the NR of mutant mice. (L) Ratio between the width of each NR and its corresponding juxtaparanodes. Errors are given as mean +/- SEM. ***, P<0.001. Bars: (A,C and I-K) 1 um; (E and G) 2 um; (B,D,F and H) 125 nm.
Copyright This image is from Lacas-Gervais S, J Cell Biol 2004 Oct 27;166(7):983-90, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:93411
Associated
Alleles
Symbol Name
Sptbn4tm1Msol spectrin beta, non-erythrocytic 4; targeted mutation 1, Michele Solimena
Associated
Genotypes
Allelic Composition Genetic Background
Sptbn4tm1Msol/Sptbn4tm1Msol involves: C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory