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| Caption | Structure of spermatids (A) and epididymal sperm (B-E) from Krt19tm1Alki/Krt19tm1Alki (K9neo/neo) mutants. The looping middle piece of the developing tail can already be seen in maturing spermatids (A). Four typical abnormalities can be seen; a hook-shaped middle piece (B), U-shaped tails formed by the close apposition of the middle piece to the principal piece and enclosing residual cytoplasm (C), "bobtail" thick sperm tail (D), and a high incidence of conjoined sperm with independent heads (E; labeled H1,H2) and middle piece of the tail (arrowheads) fused with the principal piece. F: Electron microscopy of a "U-shaped" epididymal sperm of the heterozygous (K9+/neo) mutant displaying a vesicle-containing (arrowheads) residual cytoplasm at the end of the mitochondrial-containing middle piece (Mitoch). The caudal margin of the residual cytoplasm usually does not extend beyond the annulus (the demarcation between the middle and principal piece of the sperm tail). G: Cross-section of epididymal sperm of the homozygous mutant. The dashed circles denote cross-sectioned tail middle pieces within a common cytoplasm displaying vesicles (arrowheads). This arrangement corresponds to the plasma membrane fusion of a hook-shaped sperm tails (see panel B). The dashed bracket indicates the eccentric position of a sperm tail surrounded by a wide cytoplasmic region containing vesicles (arrowheads). This pattern may represent a cross section of a "bobtail" sperm (see panel D). Panels H, I demonstrate the accumulation of myosin Va immunoreactivity (arrow) in the residual cytoplasm (similar to that shown in F). The arrowhead points to the lack of immunoreactivity beyond the residual cytoplasm. | ||||||
| Copyright | This image is from Rivkin E, Mol Reprod Dev 2005 Oct;72(2):259-71, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:125621 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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