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| Caption | Electron micrographs of yolk sac visceral endodermal cells from wild-type and Apobtm3Sgy/Apobtm3Sgy mice. Embryos were dissected in saline. Portions of the yolk sac membranes were removed for genotype analysis of Southern blotting, and the remainder were transferred to a fixation buffer. Sections were stained for lipids using imidazole-buffered osmium tetroxide. Sections from wild-type (A), Apobtm3Sgy/Apob+ (+/-, B), and Apobtm3Sgy/Apobtm3Sgy (-/-, C) yolk sacs are shown. Intracellular cytosolic lipid droplets (LD) located at the basal aspect of the visceral endodermal cells are rarely observed in wild-type cells but are evident in increasing amounts in heterozygous and homozygous mutant cells. Arrows point to Golgi apparatus regions, which stain for lipids intensely in wild-type cells, much less intensely in heterozygous cells, and not at all in homozygous cells. Magnification, 5,600x. | ||||||
| Copyright | This image is from Farese RV Jr, J Lipid Res 1996 Feb;37(2):347-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:84977 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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