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Phenotype Image Detail
Image
Caption Development of cataract in Pcbd1tm1Grc/Pcbd1tm1Grc mice. A: Pcbd1tm1Grc/Pcbd1tm1Grc (DCoH -/-) mouse showing unilateral lens opacity. B: Plot displaying the frequency of first visual observation of cataract in mutant mice in age intervals up to 1 year. C: Section of a mutant mouse with posterior cortical cataract (right) and a Pcbd1tm1Grc/Pcbd1+ mouse of similar age with a healthy eye (left). Transverse sections of paraffin-embedded tissue were stained with hematoxylin and eosin. Note the vacuoles visible in the iris and the Morgagnian granules of degraded and fluid filled lens tissue underlying the posterior capsule.
Copyright This image is from Bayle JH, J Biol Chem 2002 Aug 9;277(32):28884-91 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:78257
Associated
Alleles
Symbol Name
Pcbd1tm1Grc pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1; targeted mutation 1, Gerald R Crabtree
Associated
Genotypes
Allelic Composition Genetic Background
Pcbd1tm1Grc/Pcbd1tm1Grc either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory