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| Caption | Embryo analysis. A: Mapk7tm1Wnt/Mapk7+ (ERK5+/-) and Mapk7tm1Wnt/Mapk7tm1Wnt (ERK5-/-) embryos were dissected out of the yolk sac and amnion at E9.0 (top), E9.5 (middle), or E10.0 (bottom). Mutant embryos are normal at E9.0 but start appearing smaller and paler at E9.5. At E10.0, mutant embryos are much smaller than the heterozygous controls, and mutant embryos often exhibit hypotrophic hearts with an enlarged pericardial sac (arrow). B: The yolk sac of a mutant embryo at E9.5 (upper panel) displays interconnected vasculature (arrow), which disappears by E10.0 (lower panel), resulting in a smooth and pale appearance. | ||||
| Copyright | This image is from Sohn SJ, J Biol Chem 2002 Nov 8;277(45):43344-51 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:80044 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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