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| Caption | Cacna2d2ent/Cacna2d2ent (ent/ent) mice are from N6 and N7 intercrosses aged 4-6 months. A and B, mice during an episode of paroxysmal dyskinesia. C, characteristic outward pointing of the hind limbs and altered posture creating a "hunchback" appearance. D, size difference between 4 month-old mutant mice and wild-type (+/+) littermate. E, minimum, maximum, and average weights of mutant mice (open circles) as well as minimum and average weights of their unaffected littermates (closed squares) from eight N4-N7 intercross matings normalized to the heaviest littermate, which was never a mutant. Weights were recorded in 68 mice (at day 10; mutant (n=17) and healthy littermates (n=51) aged 10-30 days. Mutant mice exhibited reduced weight from day 10 on, although they continuously gained weight. F, survival curve for 32 mutant mice from N3-N5 intercrosses. The percentage of survivors among this this group of mice is charted over a period of 50 days. In this sample of mice, 52% (17 of 32) died between the age of 17 and 37 days, and no animals died thereafter during the period analyzed. G, dystrophic uteri of 9 month-old mutant females from an N9 intercross (center and bottom) and uterus of an unaffected female of the same age (top) that had never been pregnant. | ||||
| Copyright | This image is from Brill J, J Biol Chem 2004 Feb 20;279(8):7322-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:88967 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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