Phenotype Image Detail

Image

Caption

Histological sections showing exencephaly in Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf embryos. A,C and E, Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf embryos; B,D and F, control Brca1^tm2.1Cxd/Brac1⁺ Gadd45a^tm1Ajf/Gadd45a^tm1Ajf embryos. A/B, C/D and E/F, E9.5, E10.5 and E12.5 embryos, respectively, showing that brains were not developed in mutant embryos. fb, forebrain; mb, midbrain; hb, hindbrain. Bar= 32 um for A-D and 64 um for E and F. A total of 30 embryos (E9.5, n = 15; E10.5, n = 10; and E12.5, n = 5) were examined.

This image is from Wang X, J Biol Chem 2004 Jul 9;279(28):29606-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:91673

Associated
Alleles

Symbol	Name
Brca1^tm2.1Cxd	breast cancer 1, early onset; targeted mutation 2.1, Chu-Xia Deng
Gadd45a^tm1Ajf	growth arrest and DNA-damage-inducible 45 alpha; targeted mutation 1, Albert J Fornace

Associated
Genotypes

Allelic Composition	Genetic Background
Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Gadd45a^tm1Ajf/Gadd45a^tm1Ajf	involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * C57BL/6

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