Phenotype Image Detail

Image

Caption

Histological analysis of 8 day old wild-type and Pisd^{Gt1(Betageo)Jev}/Pisd^{Gt1(Betageo)Jev} embryos. Sagittal sections were made from embryos with surrounding deciduas. Tissues were fixed, embedded in paraffin, and serial sections were stained with hematoxylin/eosin. Size bars in A and C represent 500 nm, whereas for B and D size bars represent 200 nm. A and B, wild-type embryo. C and D, Pisd^{Gt1(Betageo)Jev}/Pisd^{Gt1(Betageo)Jev} embryo. A and C show overview of embryos with surrounding deciduas (Dc), placenta (P), and somites (S). B, detailed view of wild-type embryo that has developed the ectoderm (Ec), mesoderm (M), endoderm (En), and the amnion (Am). The extra-embryonic component is clearly defined. D, in mutant embryos, no differentiation of the three germ layers was observed. The extra-embryonic component is absent, and blood cells (indicated by asterisks) directly surround the embryo.

This image is from Steenbergen R, J Biol Chem 2005 Dec 2;280(48):40032-40 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:104104

Associated
Alleles

Symbol	Name
Pisd^{Gt1(Betageo)Jev}	phosphatidylserine decarboxylase; gene trap 1, Jean E Vance

Associated
Genotypes

Allelic Composition	Genetic Background
Pisd^{Gt1(Betageo)Jev}/Pisd^{Gt1(Betageo)Jev}	involves: 129S2/SvPas * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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