Phenotype Image Detail

Image

Caption

Histological comparison of lungs from wild-type and Man1a2^tm1.1Ahe/Man1a2^tm1.1Ahe mice. A and B, both wild-type (+/+) and Man1a2^tm1.1Ahe/Man1a2^tm1.1Ahe (-/-) mice display typical branching at E18.5. However, the interalveolar septae in mutant lungs are thicker than those in wild-type lungs (arrows denote comparable regions). Magnification was x100 (A) and X400 (B). C, alveolar hemorrhaging is observed within the air spaces of mutant lungs (< P0.5, magnification x400). As expected the interalveolar septae of wild-type neonatal lungs are thinner than those observed in E18.5 lungs. However, the interalveolar septae in mutant neonates remain relatively thicker than those in wild-type lungs, as indicated by arrows. Hematoxylin and eosin stained sections are shown.

This image is from Tremblay LO, J Biol Chem 2007 Jan 26;282(4):2558-66 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:119977

Associated
Alleles

Symbol	Name
Man1a2^tm1.1Ahe	mannosidase, alpha, class 1A, member 2; targeted mutation 1.1, Annette Herscovics

Associated
Genotypes

Allelic Composition	Genetic Background
Man1a2^tm1.1Ahe/Man1a2^tm1.1Ahe	involves: 129S4/SvJae * C57BL/6

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