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| Caption | Autoimmune symptoms of Tg(H2-K-DUSP5)21Wjl/0 mice. Tg(H2-K-DUSP5)21Wjl/0 mice develop skin lesions within areas of alopecia (A) and show increased plasma lgG1 anti-DNA antibody levels (B), as well as morphologic changes of skin (C and D) and kidney glomeruli (E and F) (indicated by white arrows). C, wild-type mouse skin (original magnification: x40). Tg(H2-K-DUSP5)21Wjl/0 mouse skin shows ulcerative dermatitis with lesion (black arrow), inflammatory cell infiltration (hatched arrow), and adjacent epithelium hyperplasia (gray arrow). E, wild type mouse kidney glomeruli appear very vascular, and glomerular capillaries contain many erythrocytes (red-stained cells without purple-stained nuclei) (original magnification: x400). F, Tg(H2-K-DUSP5)21Wjl/0 mice with skin abnormalities also exhibit advanced kidney glomerular lesions. Glomerular capillaries contain lower numbers of erythrocytes and display abundant infiltrates (pink-stained material). | ||||
| Copyright | This image is from Kovanen PE, J Biol Chem 2008 Jun 20;283(25):17362-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:138077 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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