Phenotype Image Detail

Image

Caption

Photographic and radiographic examination of wild-type, Klk4^tm1.1Jpsi/Klk4⁺ and Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi incisors at 7 weeks. Column A, oral photographs showing incisors. Column B, lateral view of mandibular incisors following soft tissue removal. Column C, lingual view of mandibular molars (M1-M3) following soft tissue removal. Column D, radiograph of hemimandible. No differences were detected between the wild-type (Klk4^+/+, top row) and Klk4^tm1.1Jpsi/Klk4⁺ (Klk4^+/-, middle row) mice at this scale. The dental enamel of the Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi (Klk4^-/-, bottom row) mice, however, is markedly different. It is chalky in color, and the crowns have chipped off in areas of occlusal contact.

This image is from Simmer JP, J Biol Chem 2009 Jul 10;284(28):19110-21 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:151626

Associated
Alleles

Symbol	Name
Klk4^tm1.1Jpsi	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate); targeted mutation 1.1, James P Simmer

Associated
Genotypes

Allelic Composition	Genetic Background
Klk4^tm1.1Jpsi/Klk4^tm1.1Jpsi	involves: Black Swiss * C57BL/6

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