Phenotype Image Detail

Image

Caption

The vestibular endorgans from wild-type and Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex} mice. Shown are the macula utricle (MU) and horizontal crista ampullaris (HCA) (A) posterior crista (B), and macual sacule (C) of the wild-type (Slc4a11^+/+) mouse. The arrows point to the normal appearance of the membranous labyrinth. D, in the Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex} (Slc411^-/-) mouse, the membranous labyrinth was collapsed (arrows) over normal sensory epithelia (SE) of the macula utricle and horizontal crista ampullaris. E, collapse of the membranous labyrinth (arrows) in the posterior crista ampullaris. F, collapse of the membranous labyrinth (arrows) in the macula sacule. Bar, 100 um (A and D) and 50 um (B,C,E and F).

This image is from Lopez IA, J Biol Chem 2009 Sep 25;284(39):26882-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155513

Associated
Alleles

Symbol	Name
Slc4a11^{Gt(OST443317)Lex}	solute carrier family 4, sodium bicarbonate transporter-like, member 11; gene trap OST443317, Lexicon Genetics

Associated
Genotypes

Allelic Composition	Genetic Background
Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex}	involves: 129S5/SvEvBrd * C57BL/6J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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