Phenotype Image Detail

Image

Caption

Liver architecture and lung morphology are distorted in Cebpa^tm1Kgx/Cebpa^tm1Kgx mice. A representative series of histologic sections of liver and lung tissues stained with hematoxylin and eosin. Note the acinar formation in the livers of Cebpa^tm1Kgx/Cebpa^tm1Kgx (-/-) mutants. Pulmonary histology of newborn littermates indicates hyperproliferation of type II pneumocytes in mutant mice and results in reduction in the alveolar airsapce (arrow, middle right panel) and interstitial thickening (arrow, lower right panel).

This image is from Flodby P, J Biol Chem 1996 Oct 4;271(40):24753-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:35795

Associated
Alleles

Symbol	Name
Cebpa^tm1Kgx	CCAAT/enhancer binding protein alpha; targeted mutation 1, Kleanthis G Xanthopoulos

Associated
Genotypes

Allelic Composition	Genetic Background
Cebpa^tm1Kgx/Cebpa^tm1Kgx	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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