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| Caption | Developmental defects in Sall4tm1Brd/Sall4+ mice. (a) Exencephaly in E16.5 Sall4tm1Brd/Sall4+ (m1/+) embryo. (b,c) Normal kidney (b) and hypoplastic kidney (c) of E16.5 mutant embryo. The hypoplastic kidney is smaller, without well defined zonation, scale bar, 1 mm. C, renal cortex; M, renal medulla. (d) Normal kidney from E16.5 mutant embryo exhibiting well formed glomeruli and tubules, scale bar, 500 um. (e) Hypoplastic kidney contains primitive nephrogenic vesicles and mesenchyme, scale bar, 500 um. G, glomerulus; CT, proximal and distal convoluted tubules; NV, nephrogenic vesicle; M, mesenchyme. (f) Lower anogenital tract abnormalities in adult mutant mice. The lower rectum, vagina and urethra all open into a persistent cloaca. UT, uterus; B, bladder; V, vagina, U, urethra; C, persistent cloaca; R, rectum; S, spinal column, scale bar, 1mm. (g-l) Hirschprung's disease in mutant mouse with bowel obstruction. (g,h) Enteric ganglion cells (arrow) in the intramural and submucosal plexuses of the large bowel in wild-type mouse, (g) H&E stained section, (h) acetyl cholinesterase staining, scale bar, 100 um. (i-l) Mutant mice with bowel obstruction. (i,j) Proximal dilated bowel with sparse enteric neurons (arrows), scale bar, 50 um. (k,l) Distal segment of bowel, enteric ganglion cells absent; scale bar, 50 um. | ||||
| Copyright | This image is from Warren M, Genesis 2007 Jan;45(1):51-8, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:117866 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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