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Phenotype Image Detail
Image
Caption Radiographic analysis of joint abnormalities in Bmal1tm1Bra/Bmal1tm1Bra mice. Whole-body radiographs of wild-type (Mop3 +/+, a) and Bmal1tm1Bra/Bmal1tm1Bra (Mop3 -/-, b) mice at 35 weeks of age. c-f: High-resolution radiography of thoracic vertebrae. c: Wild-type mouse and (d) mutant mouse at 26 weeks. Distinguishing calcifications of ventral longitudinal ligament and at the region where the dorsal longitudinal ligament inserts into the vertebral bodies in mutant mice. (white arrows) were observed. e: Wild-type mouse at 35 weeks of age and (f) mutant at 35 weeks. Increased trabecular density corresponds to bridging ankylosis in all directions from the vertebral body and includes calcification of vertebral disk and distortion of the anatomy of the costal chondral attachment (white arrows).
Copyright This image is from Bunger MK, Genesis 2005 Mar;41(3):122-32, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:97108
Associated
Alleles
Symbol Name
Bmal1tm1Bra basic helix-loop-helix ARNT like 1; targeted mutation 1, Christopher A Bradfield
Associated
Genotypes
Allelic Composition Genetic Background
Bmal1tm1Bra/Bmal1tm1Bra B6.129-Bmal1tm1Bra

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory