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| Caption | Morphological and histological abnormalities in Ryr1tm1.1Dhm/Ryr1+ mice. (A) Twelve-month old wild-type (WT) and (B) Ryr1tm1.1Dhm/Ryr1+ (IT/+) female littermates. The mutant mouse exhibits dorsal kyphosis and hind limb paresis. Note the flattend posture and outstretched hind limbs that fail to lift the hindquarters. (C-G) NADH-TR-stained longitudinal sections of mutant soleus myofibers from 12-month old (C-E) and 20-month-old (F and G) mice showing minicores and cores. In C-E, arrows show minicores occupying eccentric (C), peripheral (E), and central (D) postiions. In D, the minicore (arrow) shows intense peripheral staining revealing the distorted cross-striation of focally contracted myofibrils. In F and G, the arrows show cores extending longitundinally over multiple sarcomeres. (Scale bars, 10 mm). | ||||
| Copyright | This image is from Zvaritch E, Proc Natl Acad Sci U S A 2009 Dec 3;():. Copyright 2009 National Academy of Sciences, U.S.A. J:155825 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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