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| Caption | Mouse heads were embedded in paraffin, sectioned and stained with hematoxylin and eosin. (A) At E14.5, the palatal processes are still in a ventrical position. There is no obvious difference between wild-type (+/+) and Bnc2Gt(pU21)18Imeg/Bnc2Gt(pU21)18Imeg (-/-) embryos. (B) Anterior section at E15.5. Processes have begun to elevate in both mutant and wild-type. (C) E16.5 embryos. Palatal processes have elevated and fused in the wild-type. In the mutant embryo, processes have elevated but have failed to fuse because of insufficient growth toward the midline, thus causing cleft palate. (D) At P0, the wild-type mouse shows normal fused palate, whereas a cleft palate is evident in the mutant. Head and tongue of the mutant are smaller than those of the wild-type. Asterisks indicate cleft palate. | ||||
| Copyright | This image is from Vanhoutteghem A, Proc Natl Acad Sci U S A 2009 Aug 25;106(34):14432-7. Copyright 2009 National Academy of Sciences, U.S.A. J:151992 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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