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| Caption | (A-D) Whole-mount (A and C) and parasagittal sections (B and D) of E9.0 wild-type (control) and Epn1tm1Ocr/Epn1tm1Ocr Epn2tm1Ocr/Epn2tm1Ocr (DKO) embryos. The mutant embryo is smaller than its wild-type counterpart, had an open neural tube (arrows) and did not undergo axis rotation in the sagittal plane. (E-H) Whole-mount (E and G) and hematoxylin and eosin stained cross sections (F and H) of yolk sac of wild-type and mutant embryos at E9.5; staining of whole-mount yolk sacs with the pan endothelial marker PECAM1 is shown in insets of fields (F) and (H). The H&E stained cross-sections reveal presence of large vascular sinusoids in the mutant yolk sac wall instead of the network of large and small vessels visible in the wild-type sample. Large vitelline vessels are absent from mutant yolk sacs [insets of (F) and (H)]. | ||||||
| Copyright | This image is from Chen H, Proc Natl Acad Sci U S A 2009 Aug 18;106(33):13838-43. Copyright 2009 National Academy of Sciences, U.S.A. J:151951 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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