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| Caption | Phenotype of Pi4k2aGt(AK0094)Wtsi/Pi4k2aGt(AK0094)Wtsi (KO) mice. Weakness is evident from the hunched posture of the Pi4k2aGt(AK0094)Wtsi/Pi4k2aGt(AK0094)Wtsi mouse, which had its head resting on the substrate when at rest (A). The nodding tremor is absent when mutant mice are at rest, but appears when they move (B). Exposures were for 0.3 s without flash. (C) Urinary incontinence is evident from the stained fur of the mutant mouse compared with an age-matched wild-type (WT) mouse. (D) Suspended mutant mouse with clasped hind-legs drawn into its abdomen, in contrast to the normal splayed legs of a wild-type mouse. (E) Kaplan-Meier survival plot of mutant, Pi4k2aGt(AK0094)Wtsi/Pi4k2a+ (Het), and wild-type mice. Survival of mutant mice (n = 21) was reduced compared with heterozygotes (n = 29) or wild-type (n = 13) mice (P < 0.0001 for both); survival of heterozygous and wild-type mice were indistinguishable (P = 0.945). | ||||
| Copyright | This image is from Simons JP, Proc Natl Acad Sci U S A 2009 Jul 14;106(28):11535-9. Copyright 2009 National Academy of Sciences, U.S.A. J:150794 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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