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| Caption | (A) The weights of both liver and spleen from Lgmntm1Ihn/Lgmntm1Ihn mice (open bar) were significantly higher then those of age-matched wild-type controls (filled bar). *, P<0.05; ***, P<0.001, n=8. (B) Age-dependent increase of spleen weight in mutant mice. Homozygous mutant mice (filled circles) and Lgmntm1Ihn/Lgmn+ control (open circles) of various ages as indicated were euthanized and the spleens were weighed (3 month-old: +/-, n=6, -/-, n=6; 6 month-old: +/-, n=6, -/-, n=6; 9 month-old: +/-, n=3, -/-, n=10; 12 month-old: +/-, n=4, -/-, n=3; 15 month-old: +/-, n=3, -/-, n=10; 18 month-old: +/-, n=6, -/-, n=8). (C) H&E staining of the spleen from both heterozygous (+/-) and homozygous mutant (-/-). (Scale bar, 500 um). (D) H&E staining of homozygous mutant spleen showing numerous hemophagocytes. (Scale bar, 500 um). (E) Giemsa staining of splenocytes from homozygous mutant mice showing immature myeloid lineage cells. | ||||
| Copyright | This image is from Chan CB, Proc Natl Acad Sci U S A 2009 Jan 13;106(2):468-73. Copyright 2009 National Academy of Sciences, U.S.A. J:143886 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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