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Phenotype Image Detail
Image
Caption (A) The weights of both liver and spleen from Lgmntm1Ihn/Lgmntm1Ihn mice (open bar) were significantly higher then those of age-matched wild-type controls (filled bar). *, P<0.05; ***, P<0.001, n=8. (B) Age-dependent increase of spleen weight in mutant mice. Homozygous mutant mice (filled circles) and Lgmntm1Ihn/Lgmn+ control (open circles) of various ages as indicated were euthanized and the spleens were weighed (3 month-old: +/-, n=6, -/-, n=6; 6 month-old: +/-, n=6, -/-, n=6; 9 month-old: +/-, n=3, -/-, n=10; 12 month-old: +/-, n=4, -/-, n=3; 15 month-old: +/-, n=3, -/-, n=10; 18 month-old: +/-, n=6, -/-, n=8). (C) H&E staining of the spleen from both heterozygous (+/-) and homozygous mutant (-/-). (Scale bar, 500 um). (D) H&E staining of homozygous mutant spleen showing numerous hemophagocytes. (Scale bar, 500 um). (E) Giemsa staining of splenocytes from homozygous mutant mice showing immature myeloid lineage cells.
Copyright This image is from Chan CB, Proc Natl Acad Sci U S A 2009 Jan 13;106(2):468-73. Copyright 2009 National Academy of Sciences, U.S.A. J:143886
Associated
Alleles
Symbol Name
Lgmntm1Ihn legumain; targeted mutation 1, Ikuko Hara-Nishimura
Associated
Genotypes
Allelic Composition Genetic Background
Lgmntm1Ihn/Lgmntm1Ihn involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory