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| Caption | Pthlhtm2Ack/Pthlhtm2Ack mice exhibit growth retardation and premature aging. (A) Growth curves of wild-type (WT) and Pthlhtm2Ack/Pthlhtm2Ack (KI) mice. (B) Whole mount skeletons of newborn WT and mutant mice stained with alcian blue (for cartilage) and alizarin red (for calcified tissue). (C) Surviving mutant mice at 14 days of age show osteopenia and severe kyphosis (arrow). (D) Mutant mice at day 14 show loss of body mass, muscle atrophy, and a profound decrease in adipose tissue (Ad). (E) Representative micrographs of brains showing diffuse swelling of the tissue with complete obliteration of the sulci in the mutant mice. (F) Representative micrographs of skin from mutant mice showing thinner skin (green line) with hyperkeratosis of the epidermis (blue line) (magnification x100). (G) Representative micrographs of common carotid arteries (magnification, x400). (H) Representative micrographs of renal tissue sections showing endogenous B-galactosidase activity in renal cortical tubules from mutant mice, but not from wild-type mice (magnification x400). (I) Contact radiographs (left) and microCT 3D reconstruction (right) of the mandibles from wild-type and mutant mice (left and right specimen in each panel, respectively). (J) Western blot analysis of skeletal muscle extracts from LC3-I and II. Beta-Tubulin was used as loading control. | ||||
| Copyright | This image is from Miao D, Proc Natl Acad Sci U S A 2008 Dec 23;105(51):20309-14. Copyright 2008 National Academy of Sciences, U.S.A. J:142669 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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