| Image |
|
||||
| Caption | Cdsn deficiency results in stratum corneum detachment due to defective desmosome formation. (A) Macroscopic appearance of formalin-fixed Cdsntm1Mmat/Cdsntm1Mmat (-/-) newborn mouse with skin erosions on the limbs. (B) Loss of upper epidermis due to detachment of the stratum corneum from the underlying granular layer and/or within the upper granular layers in mutant mouse epidermis. Dilation of capillaries beneath the affected epidermis was also noted (arrows). (Scale bar: 100 um) (C) Electron density of each corneodesmosome from mutant mice (lower left, arrowhead) was markedly lower than that in wild-type (+/+) mice (upper left, arrowheads). In contrast, formation of cornified cell envelopes (arrows) was indistinguishable between wild-type and mutant mice. (Right) Higher magnification of the outlined areas shown in Left. (Scale bars: 100 nm). | ||||
| Copyright | This image is from Matsumoto M, Proc Natl Acad Sci U S A 2008 May 6;105(18):6720-4. Copyright 2008 National Academy of Sciences, U.S.A. J:134613 | ||||
|
Associated Alleles |
|
||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|
|
||
Analysis Tools