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| Caption | Cdsn deficiency results in stratum corneum detachment due to defective desmosome formation. (A) Macroscopic appearance of formalin-fixed Cdsntm1Mmat/Cdsntm1Mmat (-/-) newborn mouse with skin erosions on the limbs. (B) Loss of upper epidermis due to detachment of the stratum corneum from the underlying granular layer and/or within the upper granular layers in mutant mouse epidermis. Dilation of capillaries beneath the affected epidermis was also noted (arrows). (Scale bar: 100 um) (C) Electron density of each corneodesmosome from mutant mice (lower left, arrowhead) was markedly lower than that in wild-type (+/+) mice (upper left, arrowheads). In contrast, formation of cornified cell envelopes (arrows) was indistinguishable between wild-type and mutant mice. (Right) Higher magnification of the outlined areas shown in Left. (Scale bars: 100 nm). | ||||
| Copyright | This image is from Matsumoto M, Proc Natl Acad Sci U S A 2008 May 6;105(18):6720-4. Copyright 2008 National Academy of Sciences, U.S.A. J:134613 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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