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| Caption | Aqp2cph/Aqp2cph mutants have apparent congenitial obstruction at multiple levels. (A) At two weeks of age, Aqp2cph/Aqp2cph (mutant) mice are significantly smaller than wild-type (control) littermates. Scale bar: 1 cm. (B) The mutants grow slower than the controls. Triangle, controls; square, mutants. (C-E) The mutants have unilateral or bilateral hydronephrosis and hydroureter (arrow). (F) The blood urea nitrogen (BUN) level in the mutants (P5-P16) is 70.0 +/- 25.0 mg/dl (n=35), significantly (P <0.001) higher than that of the controls (P5-P16, 26.8 +/- 5.0 mg/dl; n = 29). (G and H) Kidney sections from P14 control and mutant littermates stained with hematoxylin and eosin. | ||||
| Copyright | This image is from McDill BW, Proc Natl Acad Sci U S A 2006 May 2;103(18):6952-7. Copyright 2006 National Academy of Sciences, U.S.A. J:109463 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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