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| Caption | Morphology of the Pitx3eyl/Pitx3eyl mouse. a: The Pitx3eyl/Pitx3eyl (eyl/eyl) mice have closed eyelids with no apparent eyes (anophthalmia) or very small eyes (microphthalmia). b-e: Pitx3eyl/Pitx3+ (heterozygote) and homozygous mutant mice are compared at embryonic day 14.5. In the upper panel, it is obvious that the eye of the homozygous mutant (c) is much smaller they the wild-type eye (b). In the lower panel, a transverse section through the wild-type eye (H/E staining). In contrast to the regularly formed wild-type eye (d), the eye of the homozygous mutant (e) is highly disorganized: the cornea is thicker, the lens is largely missing (only a remnant is present), and the retina is hypertrophic, filling most of the vitreous body. C, cornea; L, lens; R, retina. | ||||
| Copyright | This image is from Rosemann M, Mamm Genome 2010 Feb;21(1-2):13-27 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:156878 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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