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| Caption | (A) Gross morphology of wild-type (WT) and SucoGt(KST050)Byg/AI848100+ (Opt+/-) and SucoGt(KST050)Byg/SucoGt(KST050)Byg (Opt-/-) mice at P10. (B) Growth curves for control (wild-type and heterozygotes) and mutant mice from E18.5 to P20. P <0.0001 for all time points. (C) Cleared skeletal preparations of neonatal forelimbs stained with Alcian blue for cartilage and Alizarin red for bone. Note the delayed ossification of metacarpals and phalanges in the mutant autopod. The mutant forelimb was digitally cut and moved within the same image using Photoshop to align it with and position it in closer proximity to the wild-type forelimb. (D) Longitudinal sections from P0 femurs stained with Masson's trichrome to visualize collagen (blue) and muscle (red). Bar, 0.5 mm. (E) uCT reconstructions showing hyperplastic fracture calluses (arrows) at the costovertebral articulations of mutant mice (P20). Bars, 1 mm. (F) Longitudinal sections from P10 tibiae (top and middle) and calvaria (bottom) stained with Masson's trichrome. Bars: (top) 0.5 mm; (middle and bottom) 0.1 mm. (G) uCT reconstructions and bone structural parameters measured by quantitative uCT (n=5). *, P < 0.05; **, P<0.01. (H) Polarization microscopy of Sirius red-stained collagen fibers, showing abnormal birefringence of mutant cortical bone. Bar, 0.1 mm. | ||||
| Copyright | This image is from Sohaskey ML, J Cell Biol 2010 May 3;189(3):511-25, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:159823 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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