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Caption | Compared with wild-type (WT) embryos, Gata5tm1Eem/Gata5tm1Eem (Gata5-/-) and Gata4tm1Jml/Gata4+ (Gata4+/-) (1st to 3rd rows, respectively) mice appeared grossly normal, whereas Gata4tm1Jml/Gata4+ Gata5tm1Eem/ Gata5tm1Eem (5th row) compound mutants all died mid-gestation with no survivors past E14.5. There was progressive ventricular wall thinning, and the compact myocardium was hypoplastic with increasingly fine, abnormal trabecular structures with loss of each additional Gata5 allele in the setting of Gata4 heterozygosity (3rd to 5th rows). | ||||||
Copyright | This image is from Singh MK, J Biol Chem 2010 Jan 15;285(3):1765-72 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155855 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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