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| Caption | A, video clips of wild-type (wt) and CanxGt(KST286)Byg/CanxGt(KST286)Byg (cnx-/-) sibling mice. The full-length video is available as supplemental material. Mutant mice are smaller than their wild-type counterparts, with splaying of the hind limbs and gait instability. B, Mutant and wild-type brains isolated from 21-day-old mice, viewed from the dorsal and ventral side. There were no morphological differences in the anatomical structure between mutant and wild-type brains as examined in multiple animals. C, analysis of motor neuron number in wild-type and mutant mice. The spinal cord length is shorter in mutant mice, but the spinal motoneuron distribution and number were similar to that in wild-type mice. In red are the neurons counted on the left side of the spinal cord; in green are the neurons counted on the right side of the spinal cord. Motoneurons were counted in two sets of wild-type and mutant mice. D, sympathetic neurons from day 1 neonate mutant and wild-type mice were grown in compartmentalized cultures (Campenot cultures). Axonal growth was examined in three sets of wild-type and mutant cultures. The absence of calnexin had no effect on axonal growth. | ||||
| Copyright | This image is from Kraus A, J Biol Chem 2010 Jun 11;285(24):18928-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:164553 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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