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| Caption | A, wild-type otoconia can be easily detected under a light microscope when looking at isolated inner ears. Two bright reflected areas represent the otoconia of the saccule and utricle of newborn mice. Slc26a4loop/Slc26a4loop mutant mice lack the bright reflection, and instead, a dark hole appears when looking through the oval window (arrowheads). B, SEM of 2-month-old utricle shows thousands of otoconia (inset) that cover the sensory epithelium in a wild-type mouse, whereas a giant stone is appearing at the mutant utricle. C, imaging of the gelatinous matrix (otoconial membrane) reveals its normal structure in wild-type mice, which is characterized by typical pores. In the mutants, the otoconial membrane is dissociated and severed. D, high resolution images of the underlying hair cells show that mutant vestibular hair cells appear to be normal. Scale bars equal 500 um in panel A, 100 um in B, 5 um in C and D. n = 4. | ||||
| Copyright | This image is from Dror AA, J Biol Chem 2010 Jul 9;285(28):21724-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163655 | ||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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