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| Caption | (A) Gross morphological abnormalities in Nacatm1Dsr/Nacatm1Dsr (skNAC-/-) embryos compared with wild-type at E11.5. Lateral views and frontal views focused on the heart show hemorrhage within the pericardium. h, head; ht, heart; oft, outflow tract; rv, right ventricle; lv, left ventricle. (B) Transverse sections of wild-type and mutant (x2) E11.5 embryos stained with hemotoxlin & eosin. Note blood cells in the pericardial sac of mutants (arrow). Areas for ventricular septum and left ventricle wall are shown at higher magnification. Thin myocardial wall in mutant hearts is indicated (black bar) (vi and ix). ra, right atrium; la, left atrium; p, pericardium; ivs, interventricular septum; t, trabeculae. (Scale bars, 100 um.) (C) Histological sections of wild-type and mutant E10.0 hearts stained with either H&E, MF20 antibody, anti-pH3 antibody, or DAPI. Merged image of boxed area is shown at higher magnification. (D) Percentage proliferating myocytes was determined as the number of the pH3-positive, MF20-positive cells divided by the total number of DAPI/MF20-stained nuclei per section. Values are the average of multiple sections from each of four embryos per genotype, with error bars indicating SE (*P < 0.01). (E) qPCR analysis for mRNA levels of dysregulated genes in hearts of mutants at E10.5. Data are presented as mean of each genotype (n = 3) with SE (*P < 0.01). | ||||
| Copyright | This image is from Park CY, Proc Natl Acad Sci U S A 2010 Nov 30;107(48):20750-5. Copyright 2010 National Academy of Sciences, U.S.A. J:167169 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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