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| Caption | X-rays of 6 week-old wild-type (+/+; A, B, C) and LmnaDhe/Lmna+ (Dhe/+; D,E,F) hemisected skulls. Note lower bone mineral in cranial vault (compare A and D) in the mutant. Total skull length in D is 92% of A (white lines above, A & D). Diastema in E (mandibular arch: the upper white line in B and E) is 67% of that in B, and incisor length in E (the lower white line in B and E) is 87% of that in B. The entire margin of the parietal bone (indicated by white arrows in F) is radiolucent and visible, whereas it cannot be seen C. (G-L), Alizarin red stained skulls of 9 day-old LmnaDhe/LmnaDhe (Dhe/Dhe). (G,H), heterozygous mutant (I,J) and wild-type (K,L) mice. Overall deficient bone growth and mineralization are evident in homozygous and heterozygous skulls. Right-hand panels are slightly enlarged views of the skulls in the left panels. Note the deficient skull length and failure of mineralization to proceed, especially in the cranial vault, with large, open areas around the parietal and occipital bones (*). Bar in K=9.6 mm in A, D; 4.1 mm in B, E; 0.76 mm in C, F; 2 mm in G, I K; and 0.94 mm in H, J, L. | ||||||
| Copyright | This image is from Odgren PR, PLoS One 2010;5(4):e9959, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160175 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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