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| Caption | (A) Frontal view of wild-type, Alkbh1tm1Klng/ALkbh1+ (Alkbh1+/-) and Alkbh1tm1Klng/Alkbh1tm1Klng (Alkbh1-/-) embryos at E14.5. The heterozygous and homozygous embryos exhibit exencephaly in combination with a shortened, broad snout, while the homozygous embryo also has a bilateral microphthalmic eye phenotype and severely reduced body size. (B) Frontal view and side view of wild-type and homozygous adult mice. The homozygous mouse has a unilateral microphthalmic eye malformation. (C) Whole-mount view of fixated eyes from wild-type and homozygous adult mice demonstrating absent pupils and various degrees of eye malformations. (D) Histological analysis of paraffin-embedded eye sections. In homozygous mutant eyes, the lens is either missing or small and displaced in the eye field. Retinal cells appear degenerated or have lost their organized lamination pattern. R, retina; L, lens; C, cornea. (E) Closer view of the retina shown in d. Neural retinal cells are dysplastic with inclusions of rods and cones surrounded by outer nuclear layer cells. Retinal pigment epithelium cells are found inside the multi-layered neural retina. RC, rods and cones; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer; ONF, optic nerve fibers. Magnifications D, x2.5; E, x40. | ||||||
| Copyright | This image is from Nordstrand LM, PLoS One 2010;5(11):e13827, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:166841 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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