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Phenotype Image Detail
Image
Caption (A) Glycogen storage evidenced by PAS staining in skeletal muscle sections from wild-type (WT) and Pfkmtm1Fbos/Pfkmtm1Fbos (Pfkm-/-) mice. Scale bar 50 um. (B) Transmission electron microscopic analysis of skeletal muscle. Arrows show glycogen storage and asterisks point to mitochondria. Scale bar 1 um. (C) Mutant mice showing severe muscle cramps after exercise (5 min). (D) ATP and ADP content was determined in perchloric extracts of skeletal muscle from wild-type and mutant mice, in rest and after exercise (5 min). Results are mean +/- SEM of five mice per group. *P<0.05 vs. wild-type.
Copyright This image is from Garcia M, PLoS Genet 2009 Aug;5(8):e1000615, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:152153
Associated
Alleles
Symbol Name
Pfkmtm1Fbos phosphofructokinase, muscle; targeted mutation 1, Fatima Bosch
Associated
Genotypes
Allelic Composition Genetic Background
Pfkmtm1Fbos/Pfkmtm1Fbos involves: 129S6/SvEvTac * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory