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Phenotype Image Detail
Image
Caption Effects of Beta cell-specific ablation of Cebpb on glucose metabolism and islet morphology.(A) Pancreatic islets isolated from 24-week-old Cebpbtm1.1Maka/Cebpbtm1.1Maka control or Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (BetaCebpb-/-) mice were lysed and subjected to immunoblot analysis with antibodies to Cebpb and to Beta-actin (loading control). (B and C) Fed blood glucose (B) and plasma insulin (C) concentrations of control (open circles) or mutant (filled circles) mice at the indicated ages. Data are mean +/- SEM from at least 6 mice per genotype. (D) Immunostaining of pancreatic sections from 24-week-old control or mutant mice with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um.
Copyright This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725
Associated
Alleles
Symbol Name
Cebpbtm1.1Maka CCAAT/enhancer binding protein beta; targeted mutation 1.1, Masato Kasuga
Tg(Ins2-cre)23Herr transgene insertion 23, Pedro Luis Herrera
Associated
Genotypes
Allelic Composition Genetic Background
Cebpbtm1.1Maka/Cebpbtm1.1Maka
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J

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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory