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Caption | (A and B) Blood glucose (A) and plasma insulin (B) concentrations in wild-type (WT) (n = 7), Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Beta Cebpb-/-) (n = 9), Ins2Akita/Ins2Akita (Akita) (n = 7), and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (n = 14) mice in the fed state and at the indicated ages. Data are mean +/- SEM. *P < 0.05, ** P < 0.01, Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 versus Ins2Akita/Ins2Akita. (C) Pancreatic sections from 8-week-old wild-type (WT), Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Beta Cebpb-/-), Ins2Akita/Ins2Akita (Akita), and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Akita;Beta Cebpb-/-) mice were stained with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um. (D) Quantitation of Beta cell mass in 8-week-old WT, Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0, Ins2Akita/Ins2Akita, and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice. Data are mean +/- SEM from 5 mice per genotype. *P <0.05. (E) Insulin content of the pancreas of WT, Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0, Ins2Akita/Ins2Akita, and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice at 12 weeks of age. Data are mean +/- SEM from 4 mice per genotype. *P <0.05. | ||||||||
Copyright | This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725 | ||||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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