Phenotype Image Detail

Image

Caption

Effects of Cebpb ablation in pancreatic beta cells of Lepr^db/ Lepr^db mice. (E) Pancreatic sections from 24-week-old Lepr^db/Lepr⁺ (Lepr^+/-), Lepr^db/Lepr⁺ Cebpb^tm1.1Maka/ Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr^+/-;betaCebpb^-/-), Lepr^db/Lepr^db (Lepr^-/-) and Lepr^db/Lepr^db Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 (Lepr^-/-;betaCebpb^-/-) mice were stained with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um.

This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725

Associated
Alleles

Symbol	Name
Cebpb^tm1.1Maka	CCAAT/enhancer binding protein beta; targeted mutation 1.1, Masato Kasuga
Lepr^db	leptin receptor; diabetes
Tg(Ins2-cre)23Herr	transgene insertion 23, Pedro Luis Herrera

Associated
Genotypes

Allelic Composition	Genetic Background
Lepr^db/Lepr^db	BKS.Cg-Dock7^m +/+ Lepr^db/Jcl
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Lepr^db/Lepr^db Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24