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| Caption | Fibroblast-specific deletion of Klf5 attenuates cardiac hypertrophy and fibrosis after transverse aortic constriction in Klf5tm2.1Rng/Klf5tm2.1Rng Tg(Postn-cre)1Sjc/0 mice. Klf5tm2.1Rng/Klf5tm2.1Rng (Klf5fl/fl), and Klf5tm2.1Rng/Klf5tm2.1Rng Tg(Postn-cre)1Sjc/0 (Klf5fl/fl; Postn-Cre) mice were subjected to low-intensity transverse aortic constriction (LI-TAC) or sham operation. (A) Representative low-magnification views of hematoxylin and eosin (H&E)-stained heart sections 2 weeks after the operations. Scale bar: 1 mm. The bottom-left panel was composited from 2 photographs of the same section. (B) Representative elastic picrosirius red-stained sections and fibrotic areas. Scale bars: 100 um. (C) Fibrotic areas. (D) Heart weight/body weight ratios 2 weeks after the operations. (E) Echocardiographic analysis 2 weeks after the operations. (F) Relative cross-sectional areas of cardiomyocytes. (G) Relative expression levels of Nppa and Myh7 mRNA. Expression levels of each gene were normalized to 18s ribosomal RNA levels and then further normalized with respect to those obtained with samples from Klf5tm2.1Rng/Klf5tm2.1Rng mice subjected to sham operation. *P < 0.01 versus sham control of the same genotype; #P < 0.01 versus Klf5tm2.1Rng/Klf5tm2.1Rng mice subjected to TAC. n = 7. | ||||||
| Copyright | This image is from Takeda N, J Clin Invest 2010 Jan;120(1):254-65 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156696 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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