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| Caption | Rab25 deficiency promotes intestinal adenoma formation in ApcMin/Apc+ mice. (A) Gross appearance of small intestine from ApcMin/Apc+ (APCMin/+;Rab25+/+) and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (APCMin/+;Rab25-/-) mice. Rab25-deficient mice showed an increase in tumor numbers and size throughout the intestine. (B) Anatomical distribution of polyps in small intestine (SI) of ApcMin/Apc+ and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo mice. Polyp number was determined in the proximal, middle, and distal intestine as well as in the total intestines of ApcMin/Apc+ (+/+) (n = 7), ApcMin/Apc+ Rab25tm1Jrgo/Rab25+ (+/-) (n = 16), and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) (n = 12) mice. The distal intestine showed a greater increase in the number of polyps than the proximal intestine. ApcMin/Apc+ Rab25tm1Jrgo/Rab25+ mice also showed a significant increase in tumor numbers that was intermediate between ApcMin/Apc+ and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo mice. Data represent mean +/- SEM. (C) Representative Swiss rolls of proximal and distal intestine from ApcMin/Apc+ (+/+) and ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) mice. Both proximal and distal intestine from ApcMin/Apc+ Rab25tm1Jrgo/Rab25tm1Jrgo (-/-) mice showed an increase in tumor number. Scale bars: 1 mm. | ||||||
| Copyright | This image is from Nam KT, J Clin Invest 2010 Mar;120(3):840-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:158733 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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