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| Caption | (A-C) Comparing E17.5 Porcntm1.1Lcm/Porcn+ Edil3Tg(Sox2-cre)1Amc/0 (Porcndelta/+) embryos with wild-type (WT) reveals a range of phenotypes that include cleft palate, tail hypoplasia, omphalocele, atrophic dermis through which the liver is visible, and tail/posterior axis truncation. cp, cleft palate; de, atrophic dermis; om, omphalocele; tr, tail/posterior axis truncation; tl, tail hypoplasia. (D-F) Alcian blue/alizarin red skeletal stains of WT and mutant forelimbs. The arrow in F indicates lack of autopod, accompanied by absence of ulna. (G-H) Alcian blue/nuclear fast red staining to reveal skeletal elements, including sternum, of E15.5 WT and mutant ventral body walls sectioned at the level of the heart. he, heart; st, sternum. (I and J) Immunostaining of sections semiadjacent to G and H (approximate positions indicated by red boxes) for E-cadherin (red) and the dermis/mesenchyme marker PDGF receptor-alpha (green). de, dermis; ep, epidermis. (Scale bars: G and H, 500 um; I and J, 50 um.) | ||||||
| Copyright | This image is from Barrott JJ, Proc Natl Acad Sci U S A 2011 Jul 18;():. Copyright 2011 National Academy of Sciences, U.S.A. J:173672 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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