| Image |
|
||||||||
| Caption | (A and B) Alcian blue/alizarin red-stained forelimbs of E17.5 control or Porcntm1.1Lcm/Y Tg(Prrx1-cre)1Cjt/0 (Prx1KO) embryos. Mutant embryos exhibit shortening of all skeletal elements and loss of distal digits. hu, humerus; ra, radius; sc, scapula; ul, ulna. (C-F) Hind-limb skeleton preparations of E18.5 control or Porcntm1.1Lcm/Y Tg(Msx2-cre)5Rem/0 (Msx2KO) embryos and whole-mount in situ hybridization for the AER marker Fgf8 on E11.5 hind limbs. Note the almost complete absence of autopod in E18.5 mutant and focal loss of Fgf8 expression at E11.5. (G and H) H&E-stained sections of the ventral body wall from E18.5 control or Msx2KO embryos. The brackets in H indicate an area of severe dermal thinning in mutant body wall, such that liver almost directly abuts surface ectoderm. li, liver. (I and J) Lef1 immunostaining of dorsal skin from E18.5 control or Msx2KO embryos, revealing extensive domain of hairless Lef1-devoid epidermis in mutant (arrowhead in J indicates isolated patch of Lef1+ basal cells). (Scale bars: G and H, 500 um; I and J, 100 um.) | ||||||||
| Copyright | This image is from Barrott JJ, Proc Natl Acad Sci U S A 2011 Jul 18;():. Copyright 2011 National Academy of Sciences, U.S.A. J:173672 | ||||||||
|
Associated Alleles |
|
||||||||
|
Associated Genotypes |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools