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| Caption | (A) Percentage of proliferating Ki67 positive hepatocytes in Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+ Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+ (iTcfap2c) mice (n=5) and control (ctrl) mice (n=4) (B) Percentage of proliferating hepatocytes in cell culture, as the number of EdU positive cells. Error bars represent standard deviations. ***p<=0.0001, **p<=0.001. (C) Immunohistochemical staining of liver for Ki67 (proliferation, upper panel) and TUNEL staining positive (apoptosis, lower panel). (D) HE (middle panel) and Oil-Red O (lower panel) staining showing fat accumulation and microvisicular steatosis. (E) Tcfap2c immunohistochemistry (upper panel) and Oil-Red O staining (lower panel) of primary hepatocytes. (F) Transmission electron microscope images of mutant and ctrl liver. Hepatocytes from mutant mice are filled with lipid droplets (L); Dark and dense mitochondria in ctrl cells but bright mitochondria in mutant cells were evidence for mitochondria damage. Glycogen granules (G) were visible only in ctrl cells. Scale bars = 100 um. | ||||||
| Copyright | This image is from Holl D, PLoS One 2011;6(7):e22034, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174049 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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