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Phenotype Image Detail
Image
Caption Progressive cerebellar Purkinje cell degeneration and abnormalities of Purkinje dendritic arbors in Cers1fln/Cers1fln mice. (A-D) Calbindin D-28 immunostained sagittal sections of cerebella from three-week-old (B), four-week-old (B) and four-month-old Cers1fln/ Cers1fln (fln/fln) (C), and four-month-old wild type (+/+) (D) mice. Sections were counterstained with hematoxylin. Cerebellar lobules are indicated by Roman numerals. (E-H) Purkinje cells immunostained with calbindin D-28 from WT (E, G) and mutant (F, H) mice at P12 (E, F) and P17 (G, H). Scale bars: 1 mm (A-D); 50 um (E-H).
Copyright This image is from Zhao L, PLoS Genet 2011 May;7(5):e1002063, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172719
Associated
Alleles
Symbol Name
Cers1fln ceramide synthase 1; flincher
Associated
Genotypes
Allelic Composition Genetic Background
Cers1fln/Cers1fln NOD.Cg-Cers1fln/Sz

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory