Phenotype Image Detail

Image

Caption

(C) Whole-mount immunohistochemistry (IHC) for platelet/endothelial cell adhesion molecule (PECAM1) in Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}/Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} Tg(Tek-cre)#Rwng/0 (Tie2Cre^Tg/WTRhoj^Tg/Tg) embryos and control Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}/Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} (R26-Rhoj^Tg/Tg) embryos, at 10.5 dpc. Mutant embryos at 10.5 dpc demonstrate growth retardation with defective vascular development.

This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943

Associated
Alleles

Symbol	Name
Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Akiyoshi Uemura
Tg(Tek-cre)#Rwng	transgene insertion, Rong Wang

Associated
Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}/Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} Tg(Tek-cre)#Rwng/0	involves: C57BL/6 * CBA

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