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Phenotype Image Detail
Image
Caption (A and B) Wild-type (WT) and Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca (dKO) E13.5 embryos are shown. Dashed lines outline the liver, arrows indicate spina bifida, and the arrowhead denotes exencephaly. (C and D) BrdU staining of the neural tube sections corresponding to the areas outlined by dashed rectangles in A and B. (E) Quantification of the BrdU staining in neural tubes (three sections of each genotype). (Scale bars: 500 um.) (F and G) Liver gross morphology. (H and I) Haematoxylin and eosin-staining in liver sections. (Scale bars: 50 um.) (J) Quantification of TUNEL-positive cells in livers (three sections of each genotype). (K) Deletion of Mapk14tm2Nbr/Mapk14tm2Nbr (p38alphaKO) by Edil3Tg(Sox2-cre)1Amc was analyzed by immunoblotting in whole lysates of E13.5 embryos. Error bars indicate SD.
Copyright This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023
Associated
Alleles
Symbol Name
Edil3Tg(Sox2-cre)1Amc EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk11tm1Jsca mitogen-activated protein kinase 11; targeted mutation 1, J Simon C Arthur
Mapk14tm2Nbr mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
Associated
Genotypes
Allelic Composition Genetic Background
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory