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Phenotype Image Detail
Image
Caption (A-D) Hematoxylin and eosin staining of transverse sections of hearts from wild-type (WT), Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 (p38alphaKO), Mapk11tm1Jsca/Mapk11tm1Jsca (p38betaKO), and Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca (dKO) E13.5 littermate embryos. (E-H) Higher magnification of right ventricles showing thinner compact myocardium in p38betaKO and dKO hearts (asterisk). (I-L) Higher magnification of left ventricles showing thinner myocardium in dKO hearts (asterisk). S, septum; RV, right ventricle; LV, left ventricle. (Scale bars: A-D, 500 um; E-L, 100 um.)
Copyright This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023
Associated
Alleles
Symbol Name
Edil3Tg(Sox2-cre)1Amc EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk11tm1Jsca mitogen-activated protein kinase 11; targeted mutation 1, J Simon C Arthur
Mapk14tm2Nbr mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
Associated
Genotypes
Allelic Composition Genetic Background
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA
Mapk11tm1Jsca/Mapk11tm1Jsca involves: 129P2/OlaHsd
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory