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Phenotype Image Detail
Image
Caption Phenotypic analysis of Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr (KI/KI) mutant embryos and placenta at E11.5. (A) Severe growth retardation in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr embryos compared with Mapk14tm3.1(Mapk11)Nbr/Mapk14+ (KI/+) littermate embryos. (B-E) Hematoxylin and eosin staining of placental sections. (B and C) Abnormal layering in homozygous mutant placentas compared with heterozygous mutant placentas. (D and E) Magnification showing the reduced size of the labyrinthine layer and the thickening of the labyrinthine trophoblast in homozygous mutant placentas. Abbreviations: lt, labyrinthine trophoblast; lb, labyrinthine layer; sp, spongiotrophoblast layers. (Scale bars: 50 um).
Copyright This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023
Associated
Alleles
Symbol Name
Edil3Tg(Sox2-cre)1Amc EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk14tm3.1(Mapk11)Nbr mitogen-activated protein kinase 14; targeted mutation 3.1, Angel R Nebreda
Associated
Genotypes
Allelic Composition Genetic Background
Mapk14tm3.1(Mapk11)Nbr/Mapk14tm3.1(Mapk11)Nbr Not Specified
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory