Phenotype Image Detail

Image

Caption

A) E18.5 embryos of Fuz⁺/Fuz^{Gt(OSTGST001398)Lex} ((Fuz^+/-) and Fuz^{Gt(OSTGST001398)Lex}/Fuz^{Gt(OSTGST001398)Lex} (Fuz^-/-) mice. The Fuz^{Gt(OSTGST001398)Lex}/Fuz^{Gt(OSTGST001398)Lex} embryo has a hypoplastic maxilla and mandible, missing eyes and displaced ears. The white arrow denotes an abnormal bulge in the null mandible. B) The cleft palate is shown by the black arrow in E18.5 null embryos. (C, D) H&E staining of heterozygous (left) and homozygous (right) head sagittal sections. The bottom panels are higher magnification of the top panels. C) At E18.5, the homozygous mutant mandibles are shorter than in heterozygotes. Meckel's cartilage expends in the dorsal-ventral axis in addition to anterior-posterior axis and the ventral end of the mutant Meckel's cartilage points down and forms the mandibular bulge. The plane of section is depicted by the dotted line through the mouse drawing. TE, tongue; MC, Meckel's cartilage; LI, lower incisor.

This image is from Zhang Z, PLoS One 2011;6(9):e24608, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177881

Associated
Alleles

Symbol	Name
Fuz^{Gt(OSTGST001398)Lex}	fuzzy planar cell polarity protein; gene trap OSTGST001398, Lexicon Genetics

Associated
Genotypes

Allelic Composition	Genetic Background
Fuz^{Gt(OSTGST001398)Lex}/Fuz^{Gt(OSTGST001398)Lex}	involves: 129S5/SvEvBrd * C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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