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| Caption | (A) Representative electron micrographs from transverse sciatic nerve ultrathin section from Sirt2tm1.1Auw/Sirt2tm1.1Auw Tg(Mpz-cre)26Mes/0 (Sirt2-SCKO) mutants and Sirt2tm1.1Auw/Sirt2tm1.1Auw (Sirt2fl/fl-control) mice at postnatal ages P1, P3, and P5. Note reduction in the number of myelinated fibers in Sirt2-SCKO preparations. (Scale bar: 10 um.) (B and C) Histomorphometric quantification of myelinated fiber numbers (B) and g-ratios (C) in transverse sciatic nerve sections from mutants and control mice at postnatal ages P1-P28 (n = 3-5 mice per group tested) (*P < 0.05). (D) Representative light (Upper) and electron (Lower) microscopy of distal sciatic nerve stumps 14 d after nerve crush injury. Red arrows point to regenerated fibers. Note thinner myelin sheaths or complete absence of compact myelin (asterisks) in axons from adult Sirt2-SCKO mutant mice compared with controls. Blue arrowheads point to macrophages with typical cytoplasmic vacuolation due to phagocytosis. [Scale bars: 20 um (light microscopy) and 2 um (electron microscopy).] (E and F) Quantification of g-ratios (E) and fiber numbers (F) in distal sciatic nerve stumps at different time points after nerve crush injury in Sirt2-SCKO mutant mice and controls (n = 7-8 mice per group tested) (*P < 0.05). | ||||||
| Copyright | This image is from Beirowski B, Proc Natl Acad Sci U S A 2011 Oct 25;108(43):E952-61. Copyright 2011 National Academy of Sciences, U.S.A. J:177468 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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