Phenotype Image Detail

Image

Caption

(A and B) Trichrome staining of Tg(Tek-cre)1Ywa/0 (Tie2-cre⁺Gata5^+/+) control and Gata5^tm1.2Nemr/Gata5^tm1.2Nemr Tg(Tek-cre)1Ywa/0 (Tie2-cre⁺Gata5^fl/fl) mutant frontal sections. There were no major differences between groups in heart size or wall thickness. (C and D) Anatomical analysis revealed the presence of bicuspid aortic vale (BAV) in Gata5^tm1.1Nemr/Gata5^tm1.1Nemr Tg(Tek-cre)1Ywa/0 mice. Arrows denote points of attachment of the valve cups to the aortic wall. (E and F) Trichrome staining of transverse sections of outflow tract at E11.5. Arrow denotes abnormal fusion of the posterior intercalated cushion with the septal ridge, creating a R-N BAV. Scale bars: 1,500 um (A and B); 400 um (C and D); 75 um (E and F).

This image is from Laforest B, J Clin Invest 2011 Jul 1;121(7):2876-87 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:175663

Associated
Alleles

Symbol	Name
Gata5^tm1.1Nemr	GATA binding protein 5; targeted mutation 1.1, Mona Nemer
Tg(Tek-cre)1Ywa	transgene insertion 1, Masashi Yanagisawa

Associated
Genotypes

Allelic Composition	Genetic Background
Gata5^tm1.1Nemr/Gata5^tm1.1Nemr Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL

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