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| Caption | (A) Wild-type (WT) embryo at E8.5. Mutant Elp1tm1Id/Elp1tm1Id (B) and Elp1tm1.1Id/Elp1tm1.1Id (C) embryos at E9.5, photographed in the same magnification as the embryo shown in A. Note that mutant embryos at this stage closely resemble the WT E8.5 embryo in size and external morphology. (D) WT embryos at E9.5 (different magnification than embryos in A-C). Note that looping of the heart has already occurred at this stage. Elp1tm1Id/Elp1tm1Id (E) and Elp1tm1.1Id/Elp1tm1.1Id (F) embryos at E10.5. In the mutants, anterior cephalic development is severely compromised. In Ikbkap mutant embryos, the forward growth of heart ventricle (v) occurred in the absence of looping morphogenesis. Note the misaligned position of the outflow tract (oft) in mutant embryos compared to the embryo in D and the enlarged pericardial sac (arrowhead). (G) E10.5 Elp1tm1.1Id/Elp1tm1.1Id (left) and WT (right) littermates photographed together. (H-J) H&E-stained sagital sections of E8.5 WT (H), E9.5 Elp1tm1Id/Elp1tm1Id (I) and E9.5 WT (J) embryos. Note that at E9.5 cephalic and heart development of mutant embryos is similar to the WT E8.5 embryo in H. | ||||||
| Copyright | This image is from Dietrich P, PLoS One 2011;6(10):e27015, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178070 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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